Hybrid Polydimethylsiloxane Bioscaffold-intravascular Catheter for Cellular Therapies

Journal: ACS Applied Bio Materials
Authors: Sophia Hu, Rosita Primavera, Mehdi Razavi, Anirudh Avadhani, Jing Wang, Avnesh S Thakor

Abstract

Type-1 diabetes (T1D) is caused by immune-mediated destruction of insulin-producing beta-cells, resulting in insulin deficiency and hyperglycemia. Islet transplantation is a potential treatment for T1D, but clinical implementation is hampered by islet availability and poor islet survival post-transplantation. To overcome these issues, we developed an intravascular multiside hole catheter with an interior polydimethylsiloxane (PDMS) bioscaffold capable of housing a cellular cargo. We used computational fluid dynamics to determine an optimized catheter design, which we then fabricated. Using our hybrid PDMS bioscaffold-intravascular catheter, we demonstrated that this platform can successfully maintain in vitro islet function and viability.

Read more: https://doi.org/10.1021/acsabm.0c00725

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