Locoregional Delivery of Stem Cell-based Therapies (Video)

Published in: American Association for the Advancement of Science.

The paper published by the Thakor Lab ‘Locoregional delivery of Stem cell-based therapies.’ The birth of a new sub-specialty: Interventional Regenerative Medicine. This material relates to a paper that appeared in the Jun. 10, 2020, issue of Science Translational Medicine, published by AAAS. The paper, by N. Ng at Stanford University School of Medicine in Stanford, CA; and colleagues was titled, “Locoregional delivery of stem cell-based therapies.”

Watch Video: https://www.eurekalert.org/multimedia/pub/234450.php

Title: Locoregional Delivery of Stem Cell-based Therapies
Journal: Science Translational Medicine
Authors:  Nathan Norton Ng, Avnesh S Thakor

Abstract

Interventional regenerative medicine (IRM) uses image-guided, minimally invasive procedures for the targeted delivery of stem cell–based therapies to regenerate, replace, or repair damaged organs. Although many cellular therapies have shown promise in the preclinical setting, clinical results have been suboptimal. Most intravenously delivered cells become trapped in the lungs and reticuloendothelial system, resulting in little therapy reaching target tissues. IRM aims to increase the efficacy of cell-based therapies by locoregional stem cell delivery via endovascular, endoluminal, or direct injection into tissues. This review highlights routes of delivery, disease states, and mechanisms of action involved in the targeted delivery of stem cells.

Read more: https://doi.org/10.1126/scitranslmed.aba4564

Locoregional Delivery of Stem Cell-based Therapies